‘In and Out of the Hole’

An Exploration of Phencyclidine Derivatives

Authored by: Attilio Negri , Sulaf Assi

Handbook of Novel Psychoactive Substances

Print publication date:  October  2018
Online publication date:  October  2018

Print ISBN: 9781138068292
eBook ISBN: 9781315158082
Adobe ISBN:


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In Chapter 17, “‘In and Out of the Hole’: An Exploration on Phencyclidine Derivatives”, Attilio Negri and Sulaf Assi look at ketamine and at the latest phencyclidine derivatives. It presents an in-depth analysis in terms of both the recreational use and the uses in medical settings, including a review of the recent research on their antidepressant effect. The chapter also highlights analogies and differences between NMDA antagonists in terms of their chemical structure, desired and adverse effects, and potential clinical applications.

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