Mitochondrial Dysfunction in Chronic Disease

Authored by: Christopher Newell , Heather Leduc-Pessah , Aneal Khan , Jane Shearer

The Routledge Handbook on Biochemistry of Exercise

Print publication date:  December  2020
Online publication date:  December  2020

Print ISBN: 9780367223830
eBook ISBN: 9781003123835
Adobe ISBN:


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Mitochondria are responsible for maintaining energy homeostasis via oxidative phosphorylation. Ageing and many chronic diseases are characterized by mitochondrial dysfunction, loss in the efficiency of the electron transport system, and therefore a reduction in energy synthesis. Exercise is a well-known intervention proven to maintain mitochondrial function and density. This chapter highlights our current understanding of how mitochondria are affected by both exercise and chronic disease.

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