Resistance Exercise Training and The Regulation of Muscle Protein Synthesis

Authored by: Nathan Hodson , Daniel R. Moore , Chris McGlory

The Routledge Handbook on Biochemistry of Exercise

Print publication date:  December  2020
Online publication date:  December  2020

Print ISBN: 9780367223830
eBook ISBN: 9781003123835
Adobe ISBN:


 Download Chapter



Human skeletal muscle is a critical organ serving as a primary contributor to whole-body metabolism whilst also providing the necessary force to perform activities of daily living and exercise training. Skeletal muscle mass is regulated by rates of muscle protein synthesis (MPS) and muscle protein breakdown (MPB), both of which are highly sensitive to nutritional and especially contractile stimuli. Importantly, it is alterations in rates of MPS and not those of MPB that predominantly determine skeletal muscle size. In this chapter, we focus on how manipulating the modifiable factors of resistance exercise such as repetition load, exercise volume, and contraction mode affect rates of MPS and the adaptive response to resistance exercise training. We also draw from data generated in both pre-clinical models and humans to explore recent insights regarding the molecular mechanisms that underpin mRNA translation, the rate-controlling step in MPS. We conclude by summarizing the chapter and discussing areas worthy of future experimental research in the field of resistance exercise and skeletal muscle biology.

Search for more...
Back to top

Use of cookies on this website

We are using cookies to provide statistics that help us give you the best experience of our site. You can find out more in our Privacy Policy. By continuing to use the site you are agreeing to our use of cookies.