Abstract

Clinical and epidemiological studies related with human health or stress effects denote important sources of data. However, the crux of the fluoride-related problems relies on the extent of coverage of the affected or sensitive subpopulations. This is significant for deriving conclusions from the toxicological viewpoint.¹ Since the range of safety is frequently unknown, clinical studies fail to identify effect levels. Thus, when such data are extensively used, it may be impossible to obtain exceptionally rigorous guideline values based on the application of unsuitable uncertainty parameters or factors. However, clinical studies and epidemiological observations habitually constitute a precious provider that is used for assigning a weight of evidence for a meticulous approach.