Nanocarrier Systems for Lung Drug Delivery

Authored by: Sai HS. Boddu , Jerry Nesamony

Handbook of Lung Targeted Drug Delivery Systems

Print publication date:  October  2021
Online publication date:  October  2021

Print ISBN: 9780367490676
eBook ISBN: 9781003046547
Adobe ISBN:


 Download Chapter



Pulmonary drug delivery has attracted immense attention in recent years, particularly to use the lungs as a means of delivering drugs locally and systemically. Drugs must circumvent three main barriers in order to reach the respiratory bronchioles and the alveolar region. The anatomical barrier consisting of the tracheobronchial tree structure prevents the deposition of pollutants and deleterious particles. The pathological barrier, consisting of the mucus covering the respiratory tract epithelium, affects the clearance of deposit material and absorption profile. The immunological barrier, consisting of alveolar macrophages, acts as a defense mechanism. The integration of nanotechnology with pulmonary drug delivery can make a huge impact in terms of overcoming these barriers and enhancing the therapeutic outcomes of a drug. Drugs that are otherwise unacceptable due to the lack of solubility, toxicity and stability profile could be delivered using nanocarrier systems. This chapter mainly highlights the latest developments on the use of nanocarrier systems in pulmonary delivery. Deposition of nanocarriers in the lungs, and clearance and toxicity aspects of nanocarriers are also discussed.

Search for more...
Back to top

Use of cookies on this website

We are using cookies to provide statistics that help us give you the best experience of our site. You can find out more in our Privacy Policy. By continuing to use the site you are agreeing to our use of cookies.