Abstract

There have been several limitations associated with the conventional treatment choices available for targeted lung drug delivery systems. It is essential for both local and systemic treatment in the present-day pulmonary research to develop efficient, targeted drug delivery systems. Newer methods like aerosol absorption and nanoparticles have gained popularity in the modern scientific communities. The newer research models include use of computational fluid dynamics (CFD) and physiologically based pharmacokinetic (PBPK) models that are used to compute and mathematically analyze the drug delivery to the pulmonary system, making it more patient compliant and less toxic. This chapter focuses on the newer methods of pulmonary drug delivery using an extensive search of literature on the topic. This chapter aims to discuss the technical, physiological, and efficacy aspects of the newer pulmonary drug delivery systems that utilize the mathematical modeling. The chapter also aims to describe the mechanisms of administration of pulmonary medications along with compatibility of the drug, dosage, and devices used. Hence, this chapter provides better understanding of complex issues and challenges that are faced in the development of pulmonary drug delivery systems and offers an opportunity to the pharmaceutical scientist to understand the newer models and stimulations in the lung drug delivery systems and to aid in minimizing the clinical and technical gaps.