Chemical Clearing of Brains

Authored by: Klaus Becker , Christian Hahn , Nina Jährling , Marko Pende , Inna Sabdyusheva-Litschauer , Saiedeh Saghafi , Martina Wanis , Hans-Ulrich Dodt

Handbook of Neurophotonics

Print publication date:  May  2020
Online publication date:  May  2020

Print ISBN: 9781498718752
eBook ISBN: 9780429194702
Adobe ISBN:


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The rapid progress of optical sectioning microscopy as confocal or light sheet microscopy in combination with vast advancements in 3D computational image processing brought a renaissance of chemical clearing techniques for biological tissues in the recent years and triggered the development of a still-growing number of novel tissue-clearing protocols. This chapter gives an overview of the most common chemical tissue clearing approaches that have been published up to 2015, as well as a brief description of these protocols.

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